![]() ![]() Norrby-Teglund A, Muller MP, Mcgeer A et al (2005) Successful management of severe group A streptococcal soft tissue infections using an aggressive medical regimen including intravenous polyspecific immunoglobulin together with a conservative surgical approach. As such, it is generally considered not helpful in the management of aspirin toxicity. ![]() Clin Infect Dis 41:1373–1406ĭarenberg J, Ihendyane N, Sjölin J et al (2003) Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. Stevens DL, Bisno AL, Chambers HF et al (2005) Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Treatment of overdose is difficult due to the non-availability of an antidote. Clin Infect Dis 49:85–92īroyles LN, Van Beneden C, Beall B et al (2009) Population-based study of invasive disease due to beta-hemolytic streptococci of groups other than A and B. Mortality is high in severe cases when a lethal dose is consumed. Serum pH: Target 7.5-7.55 Urine pH: Target 7.5 Salicylate level: Cycle until <40 mg/dL (<2.9 mM). Diuresis, hemodialysis, and hemoperfusion are effective, but the latter two rarely are necessary.Skoff TH, Farley MM, Petit S et al (2009) Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990–2007. Pitfalls rapid reference (back to contents) Salicylate intoxication checklist Labs & targets (cycle q2hr until resolution) Glucose: Target >80-100 mg/dL if altered mental status. Fluid and electrolyte management is the mainstay of therapy. Blood level determinations are good prognostic indicators for acute ingestions but are of limited value in chronic, therapeutically induced salicylism. ![]() For acute ingestions, the magnitude of the poisoning is clearly dose related. With chronic, therapeutically induced salicylism, these symptoms may be mistaken for symptoms resulting from the illness for which the salicylates were administered. Alkalemia or acidemia, alkaluria or aciduria, hypoglycemia or hyperglycemia, and water and electrolyte imbalances may occur nausea, vomiting, tinnitus, hyperpnea, hyperpyrexia, disorientation, coma, and/or convulsions are common. ![]() Salicylate poisoning remains a major clinical hazard, usually resulting from accidental ingestions in preschool children, suicidal overdoses in adults and teenagers, and therapeutically acquired intoxication in all ages. ![]()
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